Departamento de Investigación Neuroquímica, Hospital de Zamudio, Arteaga Auzoa 45, 48170 Zamudio, Vizcaya, Spain.
Neurochem Res. 2010 Feb;35(2):247-53. doi: 10.1007/s11064-009-0048-z. Epub 2009 Aug 22.
We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients. The research was undertaken in a geographic area with an ethnically homogeneous population. The HVA plasma concentrations were significantly elevated in the schizophrenic patients compared to the bipolar patients. The levels of pGABA was significantly lower in the two groups of patients compared to the control group, while the pHVA/pGABA ratio was significantly greater in the both groups of patients compared to the controls. As the levels of pHVA and pGABA are partially under genetic control it is better to compare their concentrations within an homogeneous population. The values of the ratio pHVA/pGABA are compatible with the idea of an abnormal dopamine-GABA interaction in schizophrenic and bipolar patients. The pHVA/pGABA ratio may be a good peripheral marker in psychiatric research.
我们已经测定了精神分裂症和双相情感障碍患者的血浆（p）γ-氨基丁酸（GABA）和多巴胺代谢产物高香草酸（HVA）浓度，以及 pHVA/pGABA 比值。研究是在一个种族单一的地理区域进行的。与双相情感障碍患者相比，精神分裂症患者的 HVA 血浆浓度显著升高。与对照组相比，两组患者的 pGABA 水平均显著降低，而两组患者的 pHVA/pGABA 比值均显著高于对照组。由于 pHVA 和 pGABA 的水平部分受遗传控制，因此最好在同质人群中比较它们的浓度。pHVA/pGABA 比值与精神分裂症和双相情感障碍患者多巴胺-GABA 相互作用异常的观点相符。pHVA/pGABA 比值可能是精神科研究中的一个良好的外周标志物。
