Lise Michelle Larissa Zini, Baptista Talita Siara Almeida, Petersen Laura Esteves, Bauer Moisés Evandro, Ungaretti Cláudia Almeida Lopes, Torres Elton, Harter Karen, Staub Henrique Luiz
Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Rev Assoc Med Bras (1992). 2017 Sep;63(9):747-752. doi: 10.1590/1806-9282.63.09.747.
A link of psoriasis with subclinical atherosclerosis has been postulated and cytokine network might intermediate this association. Few data are available in patients with mild psoriasis. We evaluated carotid intima-media thickness (cIMT) in drug-free psoriatic individuals and controls. In parallel, we searched for associations of cIMT with disease activity indexes and serum interleukins (IL) in psoriatic patients.
An experienced radiologist performed the cIMT analyses. Cytokine concentrations were assessed by flow cytometry. Disease activity was evaluated based on psoriasis area and severity index (PASI) as well as body surface area (BSA).
Sixty-five (65) patients and 64 controls were studied. Mean age of patients (50.9 years) did not differ from controls (p=0.362). A low PASI and BSA (< 10) prevailed (69.2% and 56.9%, respectively). Median levels of IL-12p70, TNF-α, IL-1β and IL-10 were significantly lower in cases than in controls (adjusted p<0.05), while IL-6 and IL-8 medians did not differ between groups (adjusted p>0.05). Smoking habit and diabetes mellitus predominated in cases (p=0.002). An altered cIMT (≥ 0.9 mm) was more frequent in cases than in controls (23.8% versus 8.5%, adjusted p=0.045). Mean cIMT was higher in cases with a borderline significance (p=0.057). cIMT scores did not correlate to PASI (rs=0.066; p=0.250) or BSA (rs=0.175; p=0.185), but did correlate significantly with serum IL-6 (rs=0.26; p=0.005).
Subclinical atherosclerosis was more frequent in patients with mild psoriasis than controls. cIMT in psoriatic individuals correlated with serum IL-6, pointing to an eventual proatherogenic role of IL-6 in these patients. Newer studies should clarify the connection of atherogenesis with cytokines in psoriasis.
银屑病与亚临床动脉粥样硬化之间的联系已被提出，细胞因子网络可能介导这种关联。轻度银屑病患者的数据较少。我们评估了未使用药物的银屑病患者和对照组的颈动脉内膜中层厚度（cIMT）。同时，我们在银屑病患者中寻找cIMT与疾病活动指数和血清白细胞介素（IL）之间的关联。
由一位经验丰富的放射科医生进行cIMT分析。通过流式细胞术评估细胞因子浓度。根据银屑病面积和严重程度指数（PASI）以及体表面积（BSA）评估疾病活动度。
共研究了65例患者和64例对照。患者的平均年龄（50.9岁）与对照组无差异（p = 0.362）。低PASI和BSA（<10）占多数（分别为69.2%和56.9%）。病例组中IL-12p70、TNF-α、IL-1β和IL-10的中位数水平显著低于对照组（校正p<0.05），而IL-6和IL-8的中位数在两组之间无差异（校正p>0.05）。病例组中吸烟习惯和糖尿病更为常见（p = 0.002）。病例组中cIMT改变（≥0.9mm）比对照组更频繁（23.8%对8.5%，校正p = 0.045）。病例组的平均cIMT较高，具有临界显著性（p = 0.057）。cIMT评分与PASI（rs = 0.066；p = 0.250）或BSA（rs = 0.175；p = 0.185）无相关性，但与血清IL-6显著相关（rs = 0.26；p = 0.005）。
轻度银屑病患者中亚临床动脉粥样硬化比对照组更常见。银屑病患者的cIMT与血清IL-6相关，表明IL-6在这些患者中最终具有促动脉粥样硬化作用。新的研究应阐明银屑病中动脉粥样硬化与细胞因子的联系。
