委内瑞拉钩端螺旋体新种，从啮齿动物、牛和人类中分离出的中间菌群新成员。
Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans.
作者信息
Puche Rafael, Ferrés Ignacio, Caraballo Lizeth, Rangel Yaritza, Picardeau Mathieu, Takiff Howard, Iraola Gregorio
机构信息
Unidad de Estudios Genéticos y Forenses, Instituto Venezolano de Investigaciones Científicas, Venezuela.
Unidad de Bioinformática, Institut Pasteur Montevideo, Uruguay.
出版信息
Int J Syst Evol Microbiol. 2018 Feb;68(2):513-517. doi: 10.1099/ijsem.0.002528. Epub 2017 Dec 14.
Three strains, CLM-U50, CLM-R50 and IVIC-Bov1, belonging to the genus Leptospira, were isolated in Venezuela from a patient with leptospirosis, a domestic rat (Rattus norvegicus) and a cow (Bos taurus), respectively. The initial characterisation of these strains based on the rrs gene (16S rRNA) suggested their designation as a novel species within the 'intermediates' group of the genus Leptospira. Further phylogenomic characterisation based on single copy core genes was consistent with their separation into a novel species. The average nucleotide identity between these three strains was >99 %, but below 89 % with respect to any previously described leptospiral species, also supporting their designation as a novel species. Given this evidence, these three isolates were considered to represent a novel species, for which the name Leptospiravenezuelensis sp. nov. is proposed, with CLM-U50 (=CIP 111407=DSM 105752) as the type strain.
从委内瑞拉的一名钩端螺旋体病患者、一只家鼠（褐家鼠）和一头奶牛（黄牛）中分别分离出了三株属于钩端螺旋体属的菌株，即CLM-U50、CLM-R50和IVIC-Bov1。基于rrs基因（16S rRNA）对这些菌株进行的初步鉴定表明，它们应被归为钩端螺旋体属“中间类群”内的一个新物种。基于单拷贝核心基因的进一步系统基因组学鉴定结果与它们被划分为一个新物种的结论一致。这三株菌株之间的平均核苷酸同一性>99%，但与之前描述的任何钩端螺旋体物种相比均低于89%，这也支持了将它们认定为一个新物种。鉴于这些证据，这三株分离株被认为代表了一个新物种，为此提出了“委内瑞拉钩端螺旋体（Leptospira venezuelensis sp. nov.）”这一名称，并指定CLM-U50（=CIP 111407=DSM 105752）作为模式菌株。
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