[突触体中脂质过氧化过程与脂质磷脂酶水解过程的相互关系]
[The interrelationship of the processes of lipid peroxidation and lipid phospholipase hydrolysis in the synaptosomes].
作者信息
Nikushkin E V, Kryzhanovskiĭ G N, Mikhaleva L I, Bordiukov M M, Kaplun A L
出版信息
Biull Eksp Biol Med. 1989 Feb;107(2):174-7.
PMID:2923973
Abstract
The influence of Fe2+, alpha-tocopherol, phospholipase A2 and mepacrine on the activity of lipid peroxidation (LPO) and phospholipid hydrolysis (PLH) was studied in synaptosomes. It was established that there is the tight direct interconnection between LPO and PLH in synaptosomes. It is assumed that activation of endogenous phospholipases in neurons is one of the causes of uncompensated LPO-activation during epileptogenesis.
摘要
研究了Fe2+、α-生育酚、磷脂酶A2和米帕林对突触体中脂质过氧化（LPO）活性和磷脂水解（PLH）的影响。已确定突触体中LPO和PLH之间存在紧密的直接相互联系。据推测，神经元内源性磷脂酶的激活是癫痫发生过程中LPO激活未得到补偿的原因之一。
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