Altan G, Iarygin V N, Grigor'eva A V
Biull Eksp Biol Med. 1989 Feb;107(2):242-5.
The histone localization, template activity of chromatin and epinephrine fluorescence in L. Coeruleus (LC) neurons of normal a. guanethidine sympathectomized (GS) rats (15 mg/kg during 3, 8 or 14 days after birth) were studied. The absence of chromatin rearrangements connected with genome reprogramming under sympathectomy was documented by the fact that maximal doses of guanethidine gives no changes in ammoniacal silver staining pattern. However GS caused the decrease in nuclear and extranuclear template activity and in epinephrine fluorescence proportionally with GS. It is obvious that LC cells tend to form discrete classes according to their transcription levels.
对正常大鼠和经胍乙啶交感神经切除（GS）的大鼠（出生后3、8或14天给予15mg/kg）蓝斑（LC）神经元中的组蛋白定位、染色质模板活性和肾上腺素荧光进行了研究。胍乙啶最大剂量给药后氨银染色模式无变化，这证明了交感神经切除后不存在与基因组重编程相关的染色质重排。然而，GS导致核内和核外模板活性以及肾上腺素荧光与GS成比例下降。很明显，LC细胞根据其转录水平倾向于形成不同的类别。
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