Zhou Lina, Wang Gaohua, Wang Huiling
Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Neuroreport. 2018 Feb 7;29(3):160-168. doi: 10.1097/WNR.0000000000000945.
Despite a wide range of reports on depression-induced P300 changes, it is still debatable whether P300 can return to a pattern characteristic of healthy individuals following antidepressant treatment. Thus, the present study aims to compare P300 and its underlying neural activation in depressed patients before and after antidepressant treatment to explore the brain regions related to pathogenesis and to evaluate the prognosis after treatment. P300 was evoked by the oddball auditory paradigm and collected from 14 sex-matched, age-matched, and education level-matched patients and controls. P300 was also collected in the same patients after treatment. sLORETA was used to explore the source activation of P300 components. Depressed patients before and after antidepressant treatment tended to show lower P300 amplitudes compared with healthy controls, and their P300 amplitudes of F3 electrodes were correlated negatively to their scores on the 24-item Hamilton Depression Rating Scale, the Snaith-Hamilton Pleasure Scale, and the nine-item Patient Health Questionnaire. P300 amplitudes of P4 electrodes were correlated negatively with their scores on the Dysfunctional Attitude Scale. P300 source activation of depressed patients before antidepressant treatment was reduced in the left superior parietal lobule and the precuneus compared with healthy controls and depressed patients after treatment. No difference was found between healthy controls and depressed patients after treatment. The left superior parietal lobule and the precuneus might be therapeutic targets of depression.
尽管有大量关于抑郁症引起的P300变化的报道，但抗抑郁治疗后P300是否能恢复到健康个体的特征模式仍存在争议。因此，本研究旨在比较抑郁症患者在抗抑郁治疗前后的P300及其潜在的神经激活情况，以探索与发病机制相关的脑区，并评估治疗后的预后。通过奇偶数听觉范式诱发P300，并从14名性别匹配、年龄匹配和教育水平匹配的患者及对照中采集数据。在治疗后的同一批患者中也采集了P300。使用标准化低分辨率脑电磁断层成像（sLORETA）来探索P300成分的源激活情况。与健康对照相比，抗抑郁治疗前后的抑郁症患者往往表现出较低的P300波幅，并且他们F3电极的P300波幅与24项汉密尔顿抑郁量表、斯奈斯 - 汉密尔顿愉悦量表和9项患者健康问卷的得分呈负相关。P4电极的P300波幅与功能失调性态度量表的得分呈负相关。与健康对照及治疗后的抑郁症患者相比，抗抑郁治疗前的抑郁症患者在左侧顶上小叶和楔前叶的P300源激活降低。健康对照与治疗后的抑郁症患者之间未发现差异。左侧顶上小叶和楔前叶可能是抑郁症的治疗靶点。
