Zhou Lina, Wang Gaohua, Nan Cai, Wang Huiling, Liu Zhongchun, Bai Hanping
a Department of Psychiatry , Renmin Hospital of Wuhan University , Wuhan , China.
Nord J Psychiatry. 2019 Jan;73(1):1-8. doi: 10.1080/08039488.2018.1478991. Epub 2019 Jan 12.
Alterations in P300 components occur in depressed patients, but the brain regions contributing to these changes remain unclear.
Thus, the aim of the present study was to examine the underlying neural activation of P300 components in patients with depression to explore brain regions related to depression.
P300 components were evoked by an oddball auditory paradigm and recorded from 30 patients with current depression, as well as 30 age-, gender-, and education level-matched healthy controls. The standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA) method was used to explore the source activation of P300 components.
Compared with healthy controls, depressed patients tended to exhibit lower P200 and P300 amplitudes and prolonged P300 latency. In depressed patients, P200 source activations were reduced in the right insula, right precentral gyrus, left anterior cingulate, medial frontal gyrus, superior frontal gyrus, and middle frontal gyrus. Decreased source activations of P300 were identified in the right insula, postcentral gyrus, superior temporal gyrus, inferior parietal lobule, transverse temporal gyrus, cingulate gyrus, precentral gyrus, middle frontal gyrus, superior frontal gyrus, medial frontal gyrus, and paracentral gyrus.
Extensive dysfunction over the right hemisphere and bilateral prefrontal dysfunction may be involved in the pathophysiology of depression.
抑郁症患者的P300成分存在改变，但导致这些变化的脑区尚不清楚。
因此，本研究旨在检查抑郁症患者P300成分的潜在神经激活情况，以探索与抑郁症相关的脑区。
采用奇偶数听觉范式诱发P300成分，并记录30例当前患有抑郁症的患者以及30例年龄、性别和教育水平相匹配的健康对照者的数据。使用标准化低分辨率脑电磁断层扫描（sLORETA）方法来探索P300成分的源激活情况。
与健康对照者相比，抑郁症患者的P200和P300波幅往往较低，且P300潜伏期延长。在抑郁症患者中，右侧岛叶、右侧中央前回、左侧前扣带回、额内侧回、额上回和额中回的P200源激活降低。在右侧岛叶、中央后回、颞上回、顶下小叶、颞横回、扣带回、中央前回、额中回、额上回、额内侧回和中央旁回中发现P300的源激活减少。
右半球广泛功能障碍和双侧前额叶功能障碍可能参与了抑郁症的病理生理过程。
