从公共卫生基因组学到精准公共卫生：20 年的历程。
From public health genomics to precision public health: a 20-year journey.
机构信息
Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA.
出版信息
Genet Med. 2018 Jun;20(6):574-582. doi: 10.1038/gim.2017.211. Epub 2017 Dec 14.
Abstract
In this paper, we review the evolution of the field of public health genomics in the United States in the past two decades. Public health genomics focuses on effective and responsible translation of genomic science into population health benefits. We discuss the relationship of the field to the core public health functions and essential services, review its evidentiary foundation, and provide examples of current US public health priorities and applications. We cite examples of publications to illustrate how Genetics in Medicine reflected the evolution of the field. We also reflect on how public-health genomics is contributing to the emergence of "precision public health" with near-term opportunities offered by the US Precision Medicine (AllofUs) Initiative.
摘要
本文回顾了过去二十年来美国公共卫生基因组学领域的发展。公共卫生基因组学专注于有效地将基因组科学转化为人群健康效益，并负责任地进行转化。我们讨论了该领域与核心公共卫生功能和基本服务的关系，回顾了其证据基础，并提供了当前美国公共卫生重点和应用的实例。我们引用了一些出版物的例子来说明《医学遗传学》如何反映了该领域的发展。我们还反思了公共卫生基因组学如何通过美国精准医学（AllofUs）计划带来的近期机会为“精准公共卫生”的出现做出贡献。
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