hsa_circ_0074362在胃癌中的表达下调及其潜在诊断价值。
Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values.
作者信息
Xie Yi, Shao Yongfu, Sun Weiliang, Ye Guoliang, Zhang Xinjun, Xiao Bingxiu, Guo Junming
机构信息
Department of Biochemistry & Molecular Biology, & Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, PR China.
Department of Gastroenterology, the Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, PR China.
出版信息
Biomark Med. 2018 Jan;12(1):11-20. doi: 10.2217/bmm-2017-0114. Epub 2017 Dec 14.
AIM
To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer.
METHODS
The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Finally, a receiver operating characteristic curve was established.
RESULTS
Hsa_circ_0074362 levels were significantly downregulated in gastric cancer tissues, gastritis tissues and gastric cancer cell lines. Its levels were associated with lymphatic metastasis.
CONCLUSION
Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.
目的
探讨hsa_circ_0074362在胃癌筛查中的诊断价值。
方法
首先采用定量逆转录-聚合酶链反应检测127例胃癌组织及配对的癌旁正常组织、83例胃炎组织和6种胃癌细胞系中hsa_circ_0074362的表达水平。然后，分析其水平与胃癌患者临床病理因素之间的关系。最后，建立受试者工作特征曲线。
结果
hsa_circ_0074362水平在胃癌组织、胃炎组织和胃癌细胞系中显著下调。其水平与淋巴转移有关。
结论
hsa_circ_0074362可能在胃癌的发生中起作用，可能是胃癌的潜在生物标志物。
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