Dashti Fatemeh, Mirazimi Seyed Mohammad Ali, Rabiei Nikta, Fathazam Reza, Rabiei Negin, Piroozmand Haleh, Vosough Massoud, Rahimian Neda, Hamblin Michael R, Mirzaei Hamed
School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Mol Ther Nucleic Acids. 2021 Oct 8;26:892-926. doi: 10.1016/j.omtn.2021.10.004. eCollection 2021 Dec 3.
Gastrointestinal (GI) cancers, including colorectal, gastric, hepatic, esophageal, and pancreatic tumors, are responsible for large numbers of deaths around the world. Chemotherapy is the most common approach used to treat advanced GI cancer. However, chemoresistance has emerged as a critical challenge that prevents successful tumor elimination, leading to metastasis and recurrence. Chemoresistance mechanisms are complex, and many factors and pathways are involved. Among these factors, non-coding RNAs (ncRNAs) are critical regulators of GI tumor development and subsequently can induce resistance to chemotherapy. This occurs because ncRNAs can target multiple signaling pathways, affect downstream genes, and modulate proliferation, apoptosis, tumor cell migration, and autophagy. ncRNAs can also induce cancer stem cell features and affect the epithelial-mesenchymal transition. Thus, ncRNAs could possibly act as new targets in chemotherapy combinations to treat GI cancer and to predict treatment response.
胃肠道（GI）癌症，包括结直肠癌、胃癌、肝癌、食管癌和胰腺癌，在全球范围内导致大量死亡。化疗是治疗晚期胃肠道癌症最常用的方法。然而，化疗耐药已成为一个关键挑战，阻碍了肿瘤的成功消除，导致转移和复发。化疗耐药机制复杂，涉及许多因素和途径。在这些因素中，非编码RNA（ncRNAs）是胃肠道肿瘤发展的关键调节因子，随后可诱导化疗耐药。这是因为ncRNAs可以靶向多个信号通路，影响下游基因，并调节增殖、凋亡、肿瘤细胞迁移和自噬。ncRNAs还可以诱导癌症干细胞特征并影响上皮-间质转化。因此，ncRNAs有可能作为化疗联合治疗胃肠道癌症和预测治疗反应的新靶点。
