Deutch A Y, Roth R H
Neurosci Lett. 1987 Feb 24;74(2):169-74. doi: 10.1016/0304-3940(87)90144-3.
The distribution of calcitonin gene-related peptide (CGRP) in the A10 dopamine (DA) cell group region of the ventral tegmental area (VTA) of the rat was examined using immunohistochemical techniques. CGRP-like immunoreactivity was localized to axons innervating the rostral and dorsal VTA. Direct administration of CGRP to the VTA of the rat resulted in a dose-related increase in DA utilization in the medial prefrontal cortex, but not other mesocortical, mesolimbic, or striatal DA terminal field regions. These data suggest that CGRP may function to selectively modulate the activity of VTA dopaminergic neurons which innervate the prefrontal cortex.
采用免疫组织化学技术研究了降钙素基因相关肽（CGRP）在大鼠腹侧被盖区（VTA）A10多巴胺（DA）细胞群区域的分布。CGRP样免疫反应性定位于支配VTA嘴侧和背侧的轴突。将CGRP直接注射到大鼠的VTA中，导致内侧前额叶皮质中DA利用率呈剂量相关增加，但在其他中皮质、中边缘或纹状体DA终末场区域未出现这种情况。这些数据表明，CGRP可能具有选择性调节支配前额叶皮质的VTA多巴胺能神经元活性的功能。
