Agrawal Akanksha, Ziccardi Mary Rodriguez, Witzke Christian, Palacios Igor, Rangaswami Janani
Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
Division of Cardiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
J Interv Cardiol. 2018 Jun;31(3):407-415. doi: 10.1111/joic.12483. Epub 2017 Dec 15.
Cholesterol embolization syndrome (CES) is a multi-systemic disease caused by embolization of atherosclerotic plaque contents from proximal large-caliber artery to distal small to medium arteries, occurring spontaneously or more commonly after vascular intervention. This report is a comprehensive review of the reported cases of CES found in our literature search. We discuss the risk factors, clinical manifestations, management, and prognosis of CES. The major predisposing factors for CES include older age, male sex, atherosclerotic cardiovascular risk factors, anticoagulation, and femoral access route. The composite incidence of atheroembolic renal disease was 92% and mortality 63%. Our review highlights the importance to recognize this disease entity for the cardiologist and nephrologist.
胆固醇栓塞综合征（CES）是一种多系统疾病，由近端大口径动脉的动脉粥样硬化斑块成分栓塞至远端中小动脉引起，可自发发生，更常见于血管介入术后。本报告是对文献检索中发现的CES报告病例的全面综述。我们讨论了CES的危险因素、临床表现、治疗及预后。CES的主要易感因素包括老年、男性、动脉粥样硬化心血管危险因素、抗凝治疗以及股动脉入路。动脉粥样栓塞性肾病的综合发病率为92%，死亡率为63%。我们的综述强调了心脏病专家和肾脏病专家认识这一疾病实体的重要性。
