Zhang Jiaxin, Liu Yuzhe, Chen Yutong, Yuan Lei, Liu He, Wang Jincheng, Liu Qiran, Zhang Yan
Department of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.
Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, China.
Stem Cells Int. 2020 Dec 10;2020:8810813. doi: 10.1155/2020/8810813. eCollection 2020.
Adipose-derived stem cells (ADSCs) can maintain self-renewal and enhanced multidifferentiation potential through the release of a variety of paracrine factors and extracellular vesicles, allowing them to repair damaged organs and tissues. Consequently, considerable attention has increasingly been paid to their application in tissue engineering and organ regeneration. Here, we provide a comprehensive overview of the current status of ADSC preparation, including harvesting, isolation, and identification. The advances in preclinical and clinical evidence-based ADSC therapy for bone, cartilage, myocardium, liver, and nervous system regeneration as well as skin wound healing are also summarized. Notably, the perspectives, potential challenges, and future directions for ADSC-related researches are discussed. We hope that this review can provide comprehensive and standardized guidelines for the safe and effective application of ADSCs to achieve predictable and desired therapeutic effects.
脂肪来源干细胞（ADSCs）可通过释放多种旁分泌因子和细胞外囊泡来维持自我更新并增强多向分化潜能，从而使其能够修复受损器官和组织。因此，人们越来越关注它们在组织工程和器官再生中的应用。在此，我们全面概述了ADSC制备的现状，包括采集、分离和鉴定。还总结了基于临床前和临床证据的ADSC治疗在骨、软骨、心肌、肝脏和神经系统再生以及皮肤伤口愈合方面的进展。值得注意的是，文中还讨论了ADSC相关研究的前景、潜在挑战和未来方向。我们希望这篇综述能够为ADSCs的安全有效应用提供全面且标准化的指导方针，以实现可预测且理想的治疗效果。
