Kato T, Migita H, Ohgaki H, Sato S, Takayama S, Sugimura T
Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan.
Carcinogenesis. 1989 Mar;10(3):601-3. doi: 10.1093/carcin/10.3.601.
A mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, which was first isolated from broiled sardines and was shown to be carcinogenic to mice, was also found to be carcinogenic to F344 rats. It induced tumors in various organs, such as the Zymbal gland, oral cavity, colon, skin and mammary gland of male and female rats when given at 0.03% in the diet. However, it was noteworthy that tumors were not observed in the liver. Most of the tumors in the Zymbal gland, oral cavity and skin were squamous cell carcinomas, and most of the mammary gland tumors were adenocarcinomas. The colon tumors were identified as adenomas or adenocarcinomas. In control rats no tumors developed in these organs during the 40-week experiment.
一种诱变化合物，2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉，最初是从烤沙丁鱼中分离出来的，已证明对小鼠具有致癌性，后来也发现对F344大鼠具有致癌性。当以0.03%的剂量添加到饮食中时，它会在雄性和雌性大鼠的各种器官中诱发肿瘤，如鼓室腺、口腔、结肠、皮肤和乳腺。然而，值得注意的是，肝脏中未观察到肿瘤。鼓室腺、口腔和皮肤中的大多数肿瘤为鳞状细胞癌，乳腺肿瘤大多为腺癌。结肠肿瘤被鉴定为腺瘤或腺癌。在40周的实验期间，对照大鼠的这些器官中未出现肿瘤。
