烤沙丁鱼、煎牛肉和牛肉提取物中2-氨基-3-甲基咪唑[4,5-f]喹啉对F344大鼠致癌性的证明。
Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.
作者信息
Takayama S, Nakatsuru Y, Masuda M, Ohgaki H, Sato S, Sugimura T
出版信息
Gan. 1984 Jun;75(6):467-70.
PMID:6468834
Abstract
The mutagenic compound 2-amino-3-methylimidazo[4,5-f]quinoline, originally isolated from broiled sardines and also present in cooked beef and beef extract, is being tested for carcinogenicity in F344 rats of both sexes. High incidences of tumors of the Zymbal gland, colon, small intestine and liver in males have been observed in the first 300 days of the experiment.
摘要
诱变化合物2-氨基-3-甲基咪唑并[4,5-f]喹啉最初是从烤沙丁鱼中分离出来的，也存在于熟牛肉和牛肉提取物中，目前正在对雌雄F344大鼠进行致癌性测试。在实验的前300天，雄性大鼠中观察到了高发病率的耳下腺、结肠、小肠和肝脏肿瘤。
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