Kato T, Ohgaki H, Hasegawa H, Sato S, Takayama S, Sugimura T
Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan.
Carcinogenesis. 1988 Jan;9(1):71-3. doi: 10.1093/carcin/9.1.71.
Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished on day 429. In experimental animals, the incidence of liver, Zymbal gland, clitoral gland and skin tumors was significantly higher than in control animals. The incidence of liver tumors was 100% in males and 53% in females; most liver tumors of males were hepatocellular carcinomas and all liver tumors of females were neoplastic nodules. The incidence of Zymbal gland tumors was 75% in males and 53% in females. Clitoral gland tumors were induced in 63% and skin tumors were observed in 35% of males and 5% of females. Most of these three types of tumors were diagnosed as squamous cell carcinoma. In the control rats, liver, Zymbal gland, clitoral gland and skin tumors were not observed in either sex.
2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉（MeIQx）是一种强效诱变剂，最初从煎牛肉中分离出来，广泛存在于各种熟食中。对F344大鼠的雌雄两性进行了MeIQx致癌性测试。大鼠连续喂食含0.04% MeIQx的饲料或基础饲料，实验在第429天结束。在实验动物中，肝脏、鼓室腺、阴蒂腺和皮肤肿瘤的发生率显著高于对照动物。雄性肝脏肿瘤发生率为100%，雌性为53%；雄性的大多数肝脏肿瘤为肝细胞癌，雌性的所有肝脏肿瘤均为肿瘤性结节。雄性鼓室腺肿瘤发生率为75%，雌性为53%。雄性中有63%诱发阴蒂腺肿瘤，雄性中有35%、雌性中有5%观察到皮肤肿瘤。这三种类型的肿瘤大多被诊断为鳞状细胞癌。在对照大鼠中，雌雄两性均未观察到肝脏、鼓室腺、阴蒂腺和皮肤肿瘤。
