伤口愈合的分子机制综述：新的治疗靶点？

Review of the molecular mechanisms in wound healing: new therapeutic targets?

作者信息

Palmieri B, Vadalà M, Laurino C

机构信息

Associated Professor, Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, Università degli Studi di Modena e Reggio Emilia, Modena, Italy; Network del Secondo Parere, Modena (MO), Italy.

Biologist Researcher, Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, Università degli Studi di Modena e Reggio Emilia, Modena, Italy; Network del Secondo Parere, Modena (MO), Italy.

出版信息

J Wound Care. 2017 Dec 2;26(12):765-775. doi: 10.12968/jowc.2017.26.12.765.

DOI:10.12968/jowc.2017.26.12.765

PMID:29244975

Abstract

The restoration of the skin barrier in acute and chronic wounds is controlled by several molecular mechanisms that synergistically regulate cell kinetics, enzymatic functions, and neurovascular activation. These pathways include genetic and epigenetic activation, which modulate physiological wound healing. Our review describes the genetic background of skin repair, namely transcription-independent diffusible damage signals, individual variability, epigenetic mechanism, controlled qualitative traits, post-translational mechanisms, antioxidants, nutrients, DNA modifications, bacteria activation, mitochondrial activity, and oxidative stress. The DNA background modulating skin restoration could be used to plan new diagnostics and therapeutics.

摘要

急性和慢性伤口中皮肤屏障的修复受多种分子机制控制，这些机制协同调节细胞动力学、酶功能和神经血管激活。这些途径包括遗传和表观遗传激活，它们调节生理性伤口愈合。我们的综述描述了皮肤修复的遗传背景，即转录非依赖性可扩散损伤信号、个体变异性、表观遗传机制、可控质量性状、翻译后机制、抗氧化剂、营养素、DNA修饰、细菌激活、线粒体活性和氧化应激。调节皮肤修复的DNA背景可用于规划新的诊断方法和治疗方法。