Anderson W I, Scott D W, Luther P B
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Cornell Vet. 1989 Apr;79(2):179-84.
Histologically, multiple wart-like papules or hyperkeratotic plaques on the ear pinnae from 4 dogs were characterized as idiopathic benign lichenoid keratosis. Common histologic features included a discrete lesion of irregular and papillated epidermal hyperplasia with a moderate diffuse lichenoid interface inflammatory infiltrate consisting of lymphocytes and plasma cells. There was also focal hydropic degeneration of the epidermal basal cell layer, pigmentary incontinence, and mixed orthokeratotic and parakeratotic hyperkeratosis. In all 4 dogs, the pinnal lesions were unilateral and asymptomatic. Complete surgical excision was curative.
组织学上，4只犬耳廓上的多个疣状丘疹或角化过度斑块被诊断为特发性良性苔藓样角化病。常见的组织学特征包括一个离散的病变，表现为不规则的乳头状表皮增生，伴有由淋巴细胞和浆细胞组成的中度弥漫性苔藓样界面炎性浸润。还存在表皮基底细胞层的局灶性水肿变性、色素失禁，以及混合性正角化和不全角化过度。在所有4只犬中，耳廓病变均为单侧且无症状。完整的手术切除可治愈该病。
