Frigy A F, Cooper P H
Am J Clin Pathol. 1985 Apr;83(4):439-43. doi: 10.1093/ajcp/83.4.439.
The microscopic spectrum of benign lichenoid keratosis (BLK) was studied by examination of 30 examples. BLK consists of a segment of hyperplastic epidermis accompanied by a lymphoid infiltrate in the papillary dermis. Although termed "lichen planus-like," saw-tooth acanthosis predominated in only seven lesions, whereas irregular acanthosis was widespread in 23. The infiltrate had both a band-like (lichenoid) and perivascular arrangement, but a lichenoid appearance predominated in only half the specimens. Liquefaction of the basal layer was widespread, and hydropic change often involved the midepidermis. Mild cytologic atypicality was present in each case, but other features of actinic keratosis were lacking. Changes of senile lentigo were observed adjacent to 17 lesions. Partial involution was present in several cases. BLK often is confused clinically with a variety of other cutaneous tumors. Nevertheless, the diagnosis usually can be made on histologic grounds alone when the history indicates a solitary lesion.
通过对30例良性苔藓样角化病(BLK)进行检查,研究了其微观光谱。BLK由一段增生性表皮组成,伴有乳头真皮层的淋巴细胞浸润。尽管被称为“扁平苔藓样”,但锯齿状棘皮症仅在7个病变中占主导,而不规则棘皮症在23个病变中广泛存在。浸润具有带状(苔藓样)和血管周围排列,但仅在一半的标本中苔藓样外观占主导。基底层液化广泛存在,水肿性改变常累及表皮中层。每例均存在轻度细胞学非典型性,但缺乏光化性角化病的其他特征。在17个病变附近观察到老年性雀斑样痣的改变。几例存在部分消退。BLK在临床上常与多种其他皮肤肿瘤相混淆。然而,当病史提示为孤立性病变时,通常仅凭组织学依据即可做出诊断。