Laube B L, Links J M, LaFrance N D, Wagner H N, Rosenstein B J
Department of Medicine, Johns Hopkins University Medical Institutions, Baltimore.
Chest. 1989 Apr;95(4):822-30. doi: 10.1378/chest.95.4.822.
We characterized the bronchopulmonary distribution of a 0.9 percent saline aerosol (1.12 microM) labelled with 99mTc sulfur colloid in nine normal subjects and five patients with CF. Homogeneity of distribution was quantified using indices derived from computerized analysis of Anger camera pulmonary images including skew (a measure of distribution asymmetry) and kurtosis (a measure of distribution range). Aerosol clearance in 97 minutes (a measure of large, central airway deposition) was also assessed. Values of skew and kurtosis were reproducible for the patients with CF and were significantly elevated compared to the normal subjects. Reproducibility of skew and kurtosis were not studied in the normal subjects. Clearance was not significantly different in the two groups. We conclude that the bronchopulmonary distribution of this radioaerosol is nonuniform in patients with CF, compared to normal subjects, and clearance may be impaired in patients with CF who are severely ill.
我们对9名正常受试者和5名囊性纤维化（CF）患者中用99mTc硫胶体标记的0.9%盐水气雾剂（1.12微摩尔）的支气管肺部分布进行了表征。使用从安格尔相机肺部图像的计算机分析得出的指标对分布的均匀性进行量化，这些指标包括偏度（分布不对称性的度量）和峰度（分布范围的度量）。还评估了97分钟内的气雾剂清除率（大的中央气道沉积的度量）。CF患者的偏度和峰度值具有可重复性，并且与正常受试者相比显著升高。未对正常受试者的偏度和峰度的可重复性进行研究。两组的清除率没有显著差异。我们得出结论，与正常受试者相比，这种放射性气雾剂在CF患者中的支气管肺部分布不均匀，并且病情严重的CF患者的清除率可能受损。
