Laube B L, Links J M, Wagner H N, Norman P S, Koller D W, LaFrance N D, Adams G K
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
J Nucl Med. 1988 Jun;29(6):1057-65.
We characterized homogeneity of bronchopulmonary distribution of a 0.9% saline aerosol with a mass median aerodynamic diameter (MMAD) of 1.12 micron (sigma g = 2.04) labeled with [99mTc]sulfur colloid in nine normal subjects and nine patients with asthma. Aerosol distribution was quantified from frequency distribution histograms generated from Anger camera scans. Skew (a measure of histogram asymmetry) and kurtosis (a measure of histogram range) were significantly elevated (p less than 0.05) in the asthma patients with 0.68 +/- 0.30 and 2.62 +/- 0.81, respectively, compared with 0.39 +/- 0.12 and 1.89 +/- 0.18, respectively, in the normal subjects. Skew and kurtosis were significantly correlated with baseline forced expiratory volume in 1 sec (FEV1, an index of airway obstruction) with rs = -0.4799 (p less than 0.05) and -0.5929 (p less than 0.01), respectively. Skew and kurtosis were also significantly correlated with mucociliary clearance after approximately 90 min (an index of large, central airway deposition) with rs = 0.6801 and 0.6373, respectively (p less than 0.01). This simplified method of analysis does not require additional study days or procedures and facilitates the detection of airflow obstruction in asthma.
我们在9名正常受试者和9名哮喘患者中，对一种质量中位空气动力学直径（MMAD）为1.12微米（几何标准差σg = 2.04）、用[99mTc]硫胶体标记的0.9%盐水气雾剂的支气管肺分布均匀性进行了表征。气雾剂分布通过Anger相机扫描生成的频率分布直方图进行量化。哮喘患者的偏度（一种直方图不对称性的度量）和峰度（一种直方图范围的度量）显著升高（p < 0.05），分别为0.68 ± 0.30和2.62 ± 0.81，而正常受试者分别为0.39 ± 0.12和1.89 ± 0.18。偏度和峰度与基线1秒用力呼气量（FEV1，气道阻塞指数）显著相关，rs分别为-0.4799（p < 0.05）和-0.5929（p < 0.01）。偏度和峰度还与大约90分钟后的黏液纤毛清除率（一种大气道、中央气道沉积指数）显著相关，rs分别为0.6801和0.6373（p < 0.01）。这种简化的分析方法不需要额外的研究天数或程序，有助于检测哮喘中的气流阻塞。
