Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
Fertil Steril. 2018 Feb;109(2):343-348.e1. doi: 10.1016/j.fertnstert.2017.11.001. Epub 2017 Dec 13.
To determine whether the general public supports intergenerational oocyte donation.
Cross-sectional study.
Not applicable.
PATIENT(S): A nationally representative sample based on age distribution of United States residents.
INTERVENTIONS(S): Not applicable.
MAIN OUTCOME MEASURE(S): Characteristics of respondents who supported (strongly agree and agree) various oocyte donation practices were compared with participants who did not support them (disagree and strongly disagree) using log binomial regression to calculate risk ratios (RRs) and 95% confidence intervals of support (95% CIs). Models were adjusted for age, gender, and religion to yield adjusted risk ratios (aRR).
RESULT(S): A total of 1,915 people responded to the Web-based survey; 53% were female, and 24% were racial/ethnic minorities. Eighty-five percent had prior knowledge of oocyte donation, and 74% felt that a woman should be able to donate oocytes to a family member. The desire to help a family member was the most commonly perceived motivation for donors (79%). Christian-Catholics compared with Christian-non-Catholics (aRR 0.91, 95% CI 0.86-0.98), African Americans compared with non-Hispanic Caucasians (aRR 0.86, 95% CI 0.76-0.97), and Republicans compared with Democrats (RR 0.93, 95% CI 0.88-0.98) were less likely to support intergenerational oocyte donation. Respondents with three or more biological children (RR 1.06, 95% CI 1.00-1.11) compared with those with no children were less likely to support this practice. Eight percent of participants disapproved of donation to any family member. The most common reason for disapproval was the potential negative impact on the child (53%).
CONCLUSION(S): A majority of Americans support the practice of intergenerational oocyte donation; however, support varies according to demographic characteristics.
确定公众是否支持代际卵母细胞捐赠。
横断面研究。
不适用。
基于美国居民年龄分布的全国代表性样本。
不适用。
支持（强烈同意和同意）各种卵母细胞捐赠实践的受访者的特征与不支持这些实践的参与者进行比较，使用对数二项式回归计算支持的风险比（RR）和 95%置信区间（95%CI）。调整年龄、性别和宗教因素以得出调整后的风险比（aRR）。
共有 1915 人对网络调查做出了回应；53%为女性，24%为少数族裔。85%的人之前了解过卵母细胞捐赠，74%的人认为女性应该能够向家庭成员捐赠卵母细胞。帮助家庭成员是捐赠者最常见的动机（79%）。与基督教-天主教徒相比，基督教-非天主教徒（aRR0.91，95%CI0.86-0.98）、非西班牙裔白人与非洲裔美国人（aRR0.86，95%CI0.76-0.97）、共和党人与民主党人（RR0.93，95%CI0.88-0.98）不太支持代际卵母细胞捐赠。与没有孩子的人相比，有三个或更多亲生子女的受访者（RR1.06，95%CI1.00-1.11）不太支持这种做法。8%的参与者反对向任何家庭成员捐赠。反对的最常见原因是对孩子的潜在负面影响（53%）。
大多数美国人支持代际卵母细胞捐赠的做法；然而，支持率因人口统计学特征而异。
