Department of oral medicine and radiology, A. J. Institute of Dental Sciences, Kuntikan, Mangalore, 575004 Karnataka, India.
Department of Pedodontia, A. J. Institute of Dental Sciences, Mangalore, India.
J Stomatol Oral Maxillofac Surg. 2018 Apr;119(2):129-134. doi: 10.1016/j.jormas.2017.12.006. Epub 2017 Dec 12.
Oral submucous fibrosis (OSMF), because of its common occurrence in Indian population is known as India's disease. Regardless of diagnostic and therapeutic developments, oral potentially malignant disorders (PMD) and cancers are disseminating at a distressing rate. There is this prerequisite for unrelenting determination to find out apt treatment options so that malignant transformation may be prevented and more so the prevailing morbidity and mortality. Considering the frequency with which oral submucous fibrosis undergoes malignant transformation with free radicals playing a major part, the role of antioxidants in general and thioctic acid also known as alpha lipoic acid (ALA) in particular need to be studied in these individuals. Previous few studies indicated the use of alpha lipoic acid in oral submucous fibrosis patients leading to improvement in signs and symptoms. So, it led us to set forth and propose probable role of thioctic acid in improving symptoms in these patients. As oral submucous fibrosis poses as a threat with its various signs and symptoms and as a potentially malignant disorder as well as considering the role of free radicals in malignant transformation, we proposed the possible mechanisms behind the commonest signs and symptoms in oral submucous fibrosis and role of alpha lipoic acid in managing these signs and symptoms.
口腔黏膜下纤维性变（OSMF）在印度人群中较为常见，因此被称为印度的疾病。尽管在诊断和治疗方面取得了进展，但口腔潜在恶性疾病（PMD）和癌症仍在以令人担忧的速度传播。因此，我们必须坚持不懈地寻找合适的治疗方法，以防止恶性转化，降低目前的发病率和死亡率。考虑到口腔黏膜下纤维性变发生恶性转化的频率很高，自由基起着重要作用，抗氧化剂，特别是硫辛酸（ALA）的作用需要在这些人群中进行研究。以前的一些研究表明，在口腔黏膜下纤维性变患者中使用 ALA 可以改善症状和体征。因此，这促使我们提出并探讨硫辛酸在改善这些患者症状方面的可能作用。由于口腔黏膜下纤维性变具有多种症状和体征，且作为一种潜在的恶性疾病，同时考虑到自由基在恶性转化中的作用，我们提出了口腔黏膜下纤维性变最常见症状背后的可能机制，以及 ALA 在管理这些症状中的作用。
