Department of Dermatology and Allergy Biederstein, Technische Universität München, Germany, Munich.
J Eur Acad Dermatol Venereol. 2018 Jun;32(6):889-898. doi: 10.1111/jdv.14761. Epub 2018 Jan 17.
Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that affects men and women of all ages and also children. The clinical appearance of PRP is highly variable, as is the individual prognosis. Therefore, stratifying PRP into six disease subtypes represents a first step to personalized medicine for this rare inflammatory skin disease. The next step should be to associate specific therapeutic strategies with these subtypes of PRP. However, no randomized, controlled trials on the treatment of PRP have been performed. Consequently, the actual treatment algorithm for PRP will be based on clinical experience, small case series and case reports. The majority of published evidence is on type I PRP, whereas the treatment experience for other clinical types of PRP is still sparse and has to be gained. Nevertheless, it is now time to start developing valid algorithms as a basis for the diagnosis and treatment of PRP based on the data available. This review makes use of algorithms developed in psoriasis and atopic eczema and puts together recent insights into the pathogenesis, diagnosis and treatment experience of PRP. The innovative intention of this appraisal is to develop a structured algorithm for PRP treatment that should be further developed going forward.
红糠疹（PRP）是一种罕见的炎症性皮肤病，可影响所有年龄段的男性和女性，也可影响儿童。PRP 的临床表现高度可变，个体预后也是如此。因此，将 PRP 分为六种疾病亚型是为这种罕见的炎症性皮肤病实现个体化医学的第一步。下一步应该是将特定的治疗策略与 PRP 的这些亚型相关联。然而，针对 PRP 还没有进行过随机、对照试验。因此，PRP 的实际治疗方案将基于临床经验、小病例系列和病例报告。大多数已发表的证据都针对 I 型 PRP，而其他临床类型 PRP 的治疗经验仍然很少，需要积累。然而，现在是时候根据现有数据开始制定有效的算法，作为 PRP 诊断和治疗的基础了。本综述利用在银屑病和特应性皮炎中开发的算法，并结合了 PRP 的发病机制、诊断和治疗经验的最新见解。本评估的创新意图是开发一种用于 PRP 治疗的结构化算法，该算法应在未来进一步开发。
