University of Western Brittany, Laboratory Interactions Neurons-Keratinocytes (LINK), Brest, France; University Hospital of Brest, Department of Dermatology, Brest, France.
University Hospital of Toulouse, Department of Dermatology, Toulouse, France.
J Dermatol Sci. 2018 Mar;89(3):213-218. doi: 10.1016/j.jdermsci.2017.11.015. Epub 2017 Dec 1.
Atopic dermatitis (AD) is a chronic inflammatory skin disease causing a strong impact on quality of life. Its pathophysiology is the result of complex interactions involving immunological, genetic and environmental factors. Although there are several published in vitro three-dimensional models mimicking AD, none of them have taken all these pathophysiological features into account; thus, finding the right model may be complicated. This paper reviews the literature on the different reconstructed epidermis models of AD as well as their relevance. We focused our attention on both the defect of the epidermal barrier and the inflammation linked to the immune system.
特应性皮炎（AD）是一种慢性炎症性皮肤病，对生活质量有很大影响。其发病机制是涉及免疫、遗传和环境因素的复杂相互作用的结果。尽管有几个已发表的模拟 AD 的体外三维模型，但没有一个考虑到所有这些病理生理特征；因此，找到合适的模型可能会很复杂。本文综述了 AD 不同重建表皮模型及其相关性的文献。我们关注的是表皮屏障的缺陷和与免疫系统相关的炎症。
