Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic.
Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic.
Biotechnol Adv. 2018 May-Jun;36(3):856-870. doi: 10.1016/j.biotechadv.2017.12.006. Epub 2017 Dec 14.
Polyhydroxyalkanoates (PHA) are polyesters accumulated by numerous prokaryotes as storage materials; they attract attention as "green" alternatives to petrochemical plastics. Recent research has demonstrated that their biological role goes beyong their storage function, since they presence in cytoplasm enhances stress resistance of microorganisms. To address these complex functions, this review summarizes the protective effects of PHA for microrganisms; the involvement of PHA in stress resistance is discussed also from a praxis-oriented perspective. The review discourses the controlled application of stress to improve PHA productivity. Also the manifold advantages of using stress adapted microbes - extremophiles as PHA producers are discussed.
聚羟基脂肪酸酯（PHA）是许多原核生物作为储存物质积累的聚酯；它们作为石油化工塑料的“绿色”替代品引起了人们的关注。最近的研究表明，它们的生物作用超出了其储存功能，因为它们在细胞质中的存在增强了微生物的抗应激能力。为了应对这些复杂的功能，本综述总结了 PHA 对微生物的保护作用；还从实践的角度讨论了 PHA 参与抗应激的作用。该综述讨论了控制应激以提高 PHA 产量的应用。还讨论了使用适应应激的微生物（如极端微生物）作为 PHA 生产菌的多种优势。
