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职业性辐射暴露及其对介入医疗工作者的健康影响:一项前瞻性队列研究的研究方案

Occupational radiation exposure and its health effects on interventional medical workers: study protocol for a prospective cohort study.

作者信息

Ko Seulki, Chung Hwan Hoon, Cho Sung Bum, Jin Young Woo, Kim Kwang Pyo, Ha Mina, Bang Ye Jin, Ha Yae Won, Lee Won Jin

机构信息

Department of Preventive Medicine, Korea University College of Medicine, Seoul, South Korea.

Graduate School of Public Health, Korea University, Seoul, South Korea.

出版信息

BMJ Open. 2017 Dec 15;7(12):e018333. doi: 10.1136/bmjopen-2017-018333.

Abstract

INTRODUCTION

Although fluoroscopically guided procedures involve a considerably high dose of radiation, few studies have investigated the effects of radiation on medical workers involved in interventional fluoroscopy procedures. Previous research remains in the early stages and has not reached a level comparable with other occupational studies thus far. Furthermore, the study of radiation workers provides an opportunity to estimate health risks at low doses and dose rates of ionising radiation. Therefore, the objectives of this study are (1) to initiate a prospective cohort study by conducting a baseline survey among medical radiation workers who involve interventional fluoroscopy procedures and (2) to assess the effect of occupational radiation exposure and on the overall health status through an in-depth cross-sectional study.

METHODS AND ANALYSIS

Intervention medical workers in Korea will be enrolled by using a self-administered questionnaire survey, and the survey data will be linked with radiation dosimetry data, National Health Insurance claims data, cancer registry and mortality data. After merging these data, the radiation organ dose, lifetime attributable risk due to cancer and the risk per unit dose will be estimated. For the cross-sectional study, approximately 100 intervention radiology department workers will be investigated for blood tests, clinical examinations such as ultrasonography (thyroid and carotid artery scan) and lens opacity, the validation of badge dose and biodosimetry.

ETHICS AND DISSEMINATION

This study was reviewed and approved by the institutional review board of Korea University (KU-IRB-12-12-A-1). All participants will provide written informed consent prior to enrolment. The findings of the study will be disseminated through peer-reviewed scientific journals, conference presentations, and a report will be submitted to the relevant public health authorities in the Korea Centers for Disease Control and Prevention to help with the development of appropriate research and management policies.

摘要

引言

尽管荧光镜引导的手术涉及相当高剂量的辐射,但很少有研究调查辐射对参与介入荧光镜检查手术的医务人员的影响。以往的研究仍处于早期阶段,迄今为止尚未达到与其他职业研究相当的水平。此外,对辐射工作人员的研究为估计低剂量和低剂量率电离辐射的健康风险提供了机会。因此,本研究的目的是:(1)通过对参与介入荧光镜检查手术的医学辐射工作人员进行基线调查,启动一项前瞻性队列研究;(2)通过深入的横断面研究,评估职业辐射暴露对总体健康状况的影响。

方法与分析

韩国的介入医务人员将通过自行填写问卷调查的方式进行招募,调查数据将与辐射剂量测定数据、国民健康保险理赔数据、癌症登记数据和死亡率数据相链接。合并这些数据后,将估计辐射器官剂量、癌症导致的终生归因风险以及每单位剂量的风险。对于横断面研究,将对大约100名介入放射科工作人员进行血液检查、超声检查(甲状腺和颈动脉扫描)及晶状体混浊等临床检查,以及验证徽章剂量和生物剂量测定。

伦理与传播

本研究已获得韩国大学机构审查委员会(KU-IRB-12-12-A-1)的审查和批准。所有参与者在入组前将提供书面知情同意书。研究结果将通过同行评审的科学期刊、会议报告进行传播,并将向韩国疾病控制与预防中心的相关公共卫生当局提交一份报告,以协助制定适当的研究和管理政策。

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