Department of Preventive Medicine, Korea University College of Medicine, Seoul, South Korea.
Department of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine, San Francisco, California, USA.
Occup Environ Med. 2020 Nov;77(11):752-760. doi: 10.1136/oemed-2019-106326. Epub 2020 Jun 30.
We investigated the association between low-dose external occupational radiation exposure and circulatory disease morbidity among diagnostic medical radiation workers.
A cohort of 11 500 diagnostic medical radiation workers was linked with the National Dosimetry Registry data and the National Health Insurance Service data. Relative risks (RRs) were calculated to explore the association between occupational factors and circulatory disease morbidity, and excess relative risks per 100 milligray (ERR/100 mGy) were estimated to quantify the radiation dose-response relationship.
Overall, there were 2270 cases of circulatory diseases during 93 696 person-years of observation (average follow-up=8.1 years). RRs for hypertension were significantly increased for individuals who started working before 2000 compared with those who started in 2005 and later. ERR/100 mGy for all circulatory diseases was 0.14 (95% CI -0.57 to 0.99). Radiation risks of cerebrovascular diseases and ischaemic heart disease were non-significantly increased with estimates of individual cumulative doses to the heart (ERR/100 mGy=3.10 (-0.75 to 11.59) and 1.22 (-0.71 to 4.73), respectively). However, ERR estimates were generally more strongly positive for female versus male workers and for younger workers versus more than 50-year-old workers.
This study provides little evidence in support of a positive association between occupational radiation exposure and the overall risk of circulatory disease over a short follow-up period among medical radiation workers in South Korea. However, significantly increased RR with earlier year first worked, elevated ERR in female workers and young workers should be further followed up.
我们调查了低剂量外照射职业辐射暴露与诊断医疗辐射工作者循环系统疾病发病率之间的关系。
将一个由 11500 名诊断性医疗辐射工作者组成的队列与国家剂量计登记处数据和国家健康保险服务数据相联系。计算相对风险（RR）以探索职业因素与循环系统疾病发病率之间的关系，并估计每 100 毫戈瑞（ERR/100 mGy）的超额相对风险，以量化辐射剂量-反应关系。
总体而言，在 93696 人年的观察期间（平均随访 8.1 年），共有 2270 例循环系统疾病。与 2005 年及以后开始工作的人相比，2000 年以前开始工作的人高血压的 RR 显著增加。所有循环系统疾病的 ERR/100 mGy 为 0.14（95%CI-0.57 至 0.99）。心血管疾病和缺血性心脏病的辐射风险与心脏的个体累积剂量呈非显著正相关（ERR/100 mGy=3.10（-0.75 至 11.59）和 1.22（-0.71 至 4.73））。然而，与男性相比，女性和年轻工人的 ERR 估计值普遍更为正向，与 50 岁以上工人相比，女性和年轻工人的 ERR 估计值更为正向。
在韩国，这项研究在短时间随访期间，提供的证据很少支持职业辐射暴露与医疗辐射工作者总体循环系统疾病风险之间存在正相关关系。然而，较早年份开始工作的 RR 显著增加，女性和年轻工人的 ERR 升高，应进一步随访。
