Imperial College London, Exhibition Road, South Kensington, London SWC2AZ, UK.
Imperial College London, Exhibition Road, South Kensington, London SWC2AZ, UK; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College, London W12 0HS, UK.
HPB (Oxford). 2022 Aug;24(8):1223-1237. doi: 10.1016/j.hpb.2022.02.013. Epub 2022 Feb 28.
Surgery for patients with pancreatic cancer carries a high risk of major post-operative complications and only marginally improves overall survival. This review aims to assess the impact of surgical resection on health-related quality of life (HRQOL) of pancreatic cancer patients.
A systematic review of the literature was performed according to the PRISMA guidelines. All studies assessing QOL using validated questionnaires in pancreatic cancer patients undergoing surgical resection were included.
Twenty-two studies were assessed. Patients reported a decrease in physical, social and global scales within the first 3 months after surgery. These values showed improvement and were comparable to baseline values by 6 months. Recovery in emotional functioning towards baseline figures was demonstrated in the first 3 months post-operatively. Symptom scales including pain, fatigue and diarrhoea deteriorated after surgery, but reverted to baseline after 3-6 months.
Surgical resection for pancreatic cancer has short-term negative impact on QOL. In the longer term, this will improve and eventually recover to baseline values after 6 months. Knowledge on the impact of surgery on QOL of pancreatic cancer patients is necessary to facilitate decision-making and tailoring of surgical techniques to the individual patient.
胰腺癌患者的手术存在发生重大术后并发症的高风险，且仅略微改善总体生存率。本综述旨在评估手术切除对胰腺癌患者健康相关生活质量（HRQOL）的影响。
根据 PRISMA 指南进行系统文献回顾。所有评估使用经过验证的问卷评估接受手术切除的胰腺癌患者生活质量的研究均被纳入。
评估了 22 项研究。患者报告在手术后的前 3 个月内身体、社会和整体评分下降。这些数值在 6 个月时得到改善并与基线值相当。术后 3 个月内情绪功能恢复至基线水平。包括疼痛、疲劳和腹泻在内的症状评分在手术后恶化，但在 3-6 个月后恢复至基线。
胰腺癌的手术切除对 QOL 有短期的负面影响。从长远来看，这种影响会在 6 个月后改善并最终恢复到基线值。了解手术对胰腺癌患者 QOL 的影响对于辅助决策和根据个体患者的情况定制手术技术是必要的。
