骨肉瘤组织中的碱性磷酸酶水平与预后相关。
Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis.
作者信息
Levine A M, Rosenberg S A
出版信息
Cancer. 1979 Dec;44(6):2291-3. doi: 10.1002/1097-0142(197912)44:6<2291::aid-cncr2820440643>3.0.co;2-s.
Levels of alkaline phosphatase were measured in the primary tumor of 26 patients with osteosarcoma. One of seven patients with a tissue alkaline phosphatase level less than 0.6 microM/min/mg developed pulmonary metastases. In contrast, 16 or 17 patients with a tissue alkaline phosphatase level greater than 0.6 microM/min/mg developed pulmonary metastases. It thus appears that tissue alkaline phosphatase levels of primary osteosarcomas are strongly correlated with prognosis (p less than .01).
对26例骨肉瘤患者的原发肿瘤进行了碱性磷酸酶水平检测。组织碱性磷酸酶水平低于0.6微摩尔/分钟/毫克的7例患者中有1例发生了肺转移。相比之下，组织碱性磷酸酶水平高于0.6微摩尔/分钟/毫克的16或17例患者发生了肺转移。因此，原发性骨肉瘤的组织碱性磷酸酶水平似乎与预后密切相关（p<0.01）。
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