Liao Xun, Wei Rong, Zhou Junxiu, Wu Ke, Li Jiao
Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan, China.
Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Front Mol Biosci. 2024 Mar 7;11:1327459. doi: 10.3389/fmolb.2024.1327459. eCollection 2024.
Osteosarcoma (OS) is a highly aggressive and lethal malignant bone tumor that primarily afflicts children, adolescents, and young adults. However, the molecular mechanisms underlying OS pathogenesis remain obscure. Mounting evidence implicates dysregulated long non-coding RNAs (lncRNAs) in tumorigenesis and progression. These lncRNAs play a pivotal role in modulating gene expression at diverse epigenetic, transcriptional, and post-transcriptional levels. Uncovering the roles of aberrant lncRNAs would provide new insights into OS pathogenesis and novel tools for its early diagnosis and treatment. In this review, we summarize the significance of lncRNAs in controlling signaling pathways implicated in OS development, including the Wnt/β-catenin, PI3K/AKT/mTOR, NF-κB, Notch, Hippo, and HIF-1α. Moreover, we discuss the multifaceted contributions of lncRNAs to drug resistance in OS, as well as their potential to serve as biomarkers and therapeutic targets. This review aims to encourage further research into lncRNA field and the development of more effective therapeutic strategies for patients with OS.
骨肉瘤（OS）是一种极具侵袭性和致死性的恶性骨肿瘤，主要影响儿童、青少年和青年。然而，骨肉瘤发病机制的分子机制仍不清楚。越来越多的证据表明，长链非编码RNA（lncRNAs）失调与肿瘤发生和进展有关。这些lncRNAs在不同的表观遗传、转录和转录后水平上调节基因表达方面发挥着关键作用。揭示异常lncRNAs的作用将为骨肉瘤发病机制提供新的见解，并为其早期诊断和治疗提供新工具。在本综述中，我们总结了lncRNAs在控制与骨肉瘤发生发展相关的信号通路中的意义，包括Wnt/β-连环蛋白、PI3K/AKT/mTOR、NF-κB、Notch、Hippo和HIF-1α。此外，我们讨论了lncRNAs对骨肉瘤耐药性的多方面贡献，以及它们作为生物标志物和治疗靶点的潜力。本综述旨在鼓励对lncRNA领域进行进一步研究，并为骨肉瘤患者开发更有效的治疗策略。
