Phumlek Kalyarut, Itharat Arunporn, Pongcharoen Padcha, Chakkavittumrong Panlop, Lee Hyang-Yeol, Moon Gi-Seong, Han Min-Hui, Panthong Sumalee, Ketjinda Wichan, Davies Neal M
Student of Doctor of Philosophy Program in Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.
Department of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand.
Res Pharm Sci. 2022 Sep 8;17(5):457-467. doi: 10.4103/1735-5362.355195. eCollection 2022 Oct.
, simply known as mangosteen, has long been used by Thai traditional medicine because of its reported antibacterial and anti-inflammatory activities for the treatment of skin infections. In this study, mangosteen pericarps were developed into a hydrogel patch to eradicate acne-inducing bacteria.
The extract was investigated for bactericidal activity. A hydrogel patch containing the extract was examined for mechanical properties, antibacterial activity, release, skin permeation, and a phase I clinical study of skin irritation and allergic testing by a closed patch test.
FINDING/RESULTS: The hydrogel patch made from carrageenan and locust bean gum powders was yellow in color, smooth, durable, and flexible. This hydrogel patch was effective against , and . The active ingredient, α-mangostin, was released and permeated from the hydrogel patch within the first 30 min at 33.16 ± 0.81% and 32.96± 0.97%, respectively. The hydrogel patch showed no irritation in 30 healthy volunteers. However, two volunteers had delayed allergic contact dermatitis to 0.5% (w/w) hydrogel patch.
This hydrogel patch containing ethanolic extract is not recommended for patients who have any reaction to mangosteen but has utility as an anti-acne facial mask.
山竹，俗称莽吉柿，长期以来被泰国传统医学所使用，因其具有抗菌和抗炎活性，可用于治疗皮肤感染。在本研究中，将山竹果皮制成水凝胶贴片以根除致痘细菌。
研究山竹提取物的杀菌活性。对含有该提取物的水凝胶贴片进行机械性能、抗菌活性、药物释放、皮肤渗透测试，并通过封闭贴片试验进行皮肤刺激性和过敏测试的I期临床研究。
发现/结果：由卡拉胶和刺槐豆胶粉末制成的山竹水凝胶贴片呈黄色，光滑、耐用且有柔韧性。该山竹水凝胶贴片对痤疮丙酸杆菌、金黄色葡萄球菌和表皮葡萄球菌有效。活性成分α-倒捻子素在前30分钟内分别以33.16±0.81%和32.96±0.97%的比例从山竹水凝胶贴片中释放并渗透。该山竹水凝胶贴片在30名健康志愿者中未显示出刺激性。然而，两名志愿者对0.5%（w/w）的山竹水凝胶贴片出现了迟发性过敏性接触性皮炎。
这种含有山竹乙醇提取物的水凝胶贴片不推荐给对山竹有任何反应的患者，但可作为抗痤疮面膜使用。
