Pertosa G, Pastore A, Schena F P
Chair of Medical Therapy, University of Bari Polyclinic, Italy.
Int J Artif Organs. 1989 Jan;12(1):36-40.
Plasma fibronectin (FN) was assayed in 30 patients with chronic renal failure under conservative therapy, 60 uremic patients undergoing periodic hemodialysis, and 7 patients treated by hemofiltration. Plasma FN was significantly lower in uremic patients on conservative therapy and in those who received intermittent hemodialysis than in the control group. No difference was seen between mean FN concentrations using different dialyzer membranes. Nevertheless, plasma FN levels were significantly higher in subjects after intermittent hemofiltration. There was no evidence of activation of the coagulation system or of any correlation between FN and fibrinogen values. These findings suggest that conventional hemodialysis is not effective in improving the low levels of plasma FN found in uremic patients, whereas intermittent hemofiltration raises FN. These differences may be due to the fact that during hemofiltration, even when using the same dialyzer membranes as in conventional hemodialysis, some "substances" with high molecular weight that could block the synthesis of FN could be removed.
对30例接受保守治疗的慢性肾衰竭患者、60例接受定期血液透析的尿毒症患者以及7例接受血液滤过治疗的患者进行了血浆纤维连接蛋白（FN）检测。接受保守治疗的尿毒症患者和接受间歇性血液透析的患者的血浆FN显著低于对照组。使用不同透析器膜时，平均FN浓度未见差异。然而，间歇性血液滤过后受试者的血浆FN水平显著更高。没有证据表明凝血系统被激活，也没有发现FN与纤维蛋白原值之间存在任何相关性。这些发现表明，传统血液透析对改善尿毒症患者中发现的低水平血浆FN无效，而间歇性血液滤过可提高FN水平。这些差异可能是由于在血液滤过过程中，即使使用与传统血液透析相同的透析器膜，一些可能阻碍FN合成的高分子量“物质”也可能被清除。
