Schena F P, Pertosa G, Germinario C
Nephron. 1986;44(4):320-3. doi: 10.1159/000184013.
Plasma fibronectin (FN) concentration was measured in patients with idiopathic glomerulonephritis (GN) with or without impaired renal function, in uremic patients undergoing periodic hemodialysis and in renal transplant patients before and after an acute rejection crisis. Results show normal FN levels in idiopathic GN and in renal transplant patients with normal renal function, while significantly lower levels were found in GN with severe renal damage, in uremia before and after dialysis, and in renal transplant patients during acute and chronic graft rejection. Significant correlations between high serum creatinine values and low plasma FN levels were found in renal transplant patients. These findings suggest that the kidney may influence FN levels in the blood since acute (rejection crisis) and chronic renal failure (uremia) cause low concentrations of this protein, while levels tend to return to normal values in patients with uremia after renal transplantation. We hypothesize that the normal kidney removes or perhaps degrades some substances or hormones that may control the release or synthesis of FN. These substances are not dialyzed by cellophane membranes since low plasma FN levels persist after periodic hemodialysis. Only the renal graft provokes an increase of FN in the blood stream.
对患有或未患有肾功能损害的特发性肾小球肾炎（GN）患者、接受定期血液透析的尿毒症患者以及肾移植患者在急性排斥危机前后的血浆纤连蛋白（FN）浓度进行了测量。结果显示，特发性GN患者以及肾功能正常的肾移植患者的FN水平正常，而在伴有严重肾损害的GN患者、透析前后的尿毒症患者以及肾移植患者急性和慢性移植排斥期间，FN水平显著降低。在肾移植患者中发现血清肌酐值高与血浆FN水平低之间存在显著相关性。这些发现表明，肾脏可能会影响血液中的FN水平，因为急性（排斥危机）和慢性肾衰竭（尿毒症）会导致这种蛋白质浓度降低，而肾移植后尿毒症患者的FN水平往往会恢复到正常水平。我们推测，正常的肾脏会清除或可能降解一些可能控制FN释放或合成的物质或激素。这些物质不能被玻璃纸膜透析，因为定期血液透析后血浆FN水平仍然很低。只有肾移植会引起血流中FN的增加。
