DeBenedittis G, Panerai A A, Villamira M A
Int J Clin Exp Hypn. 1989 Jan;37(1):55-69. doi: 10.1080/00207148908410533.
Mechanisms of hypnotic analgesia are still poorly understood and conflicting data are reported regarding the underlying neurochemical correlates. The present study was designed to investigate the effects of hypnotically induced analgesia and hypnotizability on experimental ischemic pain, taking into account pain and distress tolerance as well as the neurochemical correlates. 11 high hypnotizable Ss and 10 low hypnotizable Ss, as determined by scores on the Stanford Hypnotic Susceptibility Scale, Form C (Weitzenhoffer & E. R. Hilgard, 1962), were administered an ischemic pain test in both waking and hypnotic conditions. The following variables were measured: (a) pain and distress tolerance, (b) anxiety levels, and (c) plasma concentrations of beta-endorphin and adrenocorticotropic hormone (ACTH). Results confirmed significant increases of pain and distress tolerance during hypnosis as compared to the waking state, with positive correlations between pain and distress relief and hypnotizability. Moreover, a hypnotically induced dissociation between the sensory-discriminative and the affective-motivational dimensions of pain experience was found, but only in high hypnotizable Ss. Hypnotic analgesia was unrelated to anxiety reduction and was not mediated either by endorphins or by ACTH.
催眠镇痛的机制仍未得到充分理解，关于其潜在神经化学关联的报道数据相互矛盾。本研究旨在探讨催眠诱导镇痛和催眠易感性对实验性缺血性疼痛的影响，同时考虑疼痛和痛苦耐受性以及神经化学关联。通过斯坦福催眠易感性量表C型（韦岑霍弗和E.R. 希尔加德，1962年）的得分确定了11名高催眠易感性受试者和10名低催眠易感性受试者，并在清醒和催眠状态下对他们进行了缺血性疼痛测试。测量了以下变量：（a）疼痛和痛苦耐受性，（b）焦虑水平，以及（c）β-内啡肽和促肾上腺皮质激素（ACTH）的血浆浓度。结果证实，与清醒状态相比，催眠期间疼痛和痛苦耐受性显著增加，疼痛和痛苦缓解与催眠易感性之间呈正相关。此外，发现了催眠诱导的疼痛体验的感觉辨别维度和情感动机维度之间的分离，但仅在高催眠易感性受试者中存在。催眠镇痛与焦虑减轻无关，也不是由内啡肽或ACTH介导的。
