两种不同力值下上颌后牙段牙齿远中移动的生化与临床比较

Biochemical and clinical comparisons of segmental maxillary posterior tooth distal movement between two different force magnitudes.

作者信息

Limsiriwong Suchada, Khemaleelakul Wikanda, Sirabanchongkran Supassara, Pothacharoen Peraphan, Kongtawelert Prachya, Ongchai Siriwan, Jotikasthira Dhirawat

机构信息

Doctor of Philosophy Program in Dentistry (Orthodontics), Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

出版信息

Eur J Orthod. 2018 Sep 28;40(5):496-503. doi: 10.1093/ejo/cjx092.

DOI:10.1093/ejo/cjx092

PMID:29253140

Abstract

BACKGROUND/OBJECTIVES: Maxillary tooth distal movement is a treatment option for Class II malocclusion. This prospective clinical study (split-mouth design) was aimed to compare chondroitin sulphate (CS) levels in gingival crevicular fluid (GCF), the rates of tooth movement, and patient pain and discomfort during segmental maxillary posterior tooth distal movement using either 120 or 180 g of retraction force.

MATERIALS AND METHODS

Twenty patients (6 males and 14 females; aged 18.85 ± 4.38 years) with Class II malocclusion were recruited. The force magnitudes were controlled at 120 or 180 g, randomly assigned to either the right or left five-tooth segments. Gingival crevicular fluid samples were collected with Periopaper® strips. Competitive ELISA with monoclonal antibody was used to measure CS levels in GCF. The rates of segmental maxillary posterior tooth distal movement, and the amount of pain and discomfort were evaluated.

RESULTS

The median CS levels during the segmental distal movement period were significantly greater than those before the segmental distal movement period (P < 0.05). At each 1-week period during segmental distal movement, the differences between the median CS levels induced by the two different force magnitudes were not significantly different. The rates of segmental distal movement induced by the two different force magnitudes were not significantly different. The mean visual analog scale scores for pain and discomfort with 180 g of retraction force was significantly greater than that with 120 g (P < 0.05).

CONCLUSIONS

One hundred and twenty grams of retraction force was sufficient to cause segmental distal movement, as indicated by biochemically assessed bone remodeling activity and a similar rate of tooth movement to that caused by 180 g of retraction force; it also produced less patient pain and discomfort.

TRIAL REGISTRATION

The study has been registered as TCTR20170728001.

摘要

背景/目的：上颌牙齿远中移动是治疗安氏II类错牙合的一种治疗方法。这项前瞻性临床研究（分口设计）旨在比较使用120克或180克的牵引力进行上颌后牙段远中移动时，龈沟液（GCF）中硫酸软骨素（CS）的水平、牙齿移动速率以及患者的疼痛和不适情况。

材料与方法

招募了20名安氏II类错牙合患者（6名男性和14名女性；年龄18.85±4.38岁）。牵引力大小控制在120克或180克，随机分配到右侧或左侧的五颗牙段。使用Periopaper®试纸条收集龈沟液样本。采用单克隆抗体竞争性ELISA法测量GCF中CS的水平。评估上颌后牙段远中移动的速率以及疼痛和不适的程度。

结果

在牙段远中移动期间的CS水平中位数显著高于牙段远中移动前（P<0.05）。在牙段远中移动的每个1周时间段内，两种不同牵引力大小引起的CS水平中位数差异无统计学意义。两种不同牵引力大小引起的牙段远中移动速率差异无统计学意义。180克牵引力时疼痛和不适的视觉模拟量表平均得分显著高于120克时（P<0.05）。