Yassaei S, Aghili H, Afshari J Tavakol, Bagherpour A, Eslami F
Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Daheye Fajr BLV, Imam Ave, Po Box:89195/165, Yazd, Iran.
Department of Allergy and Immunology, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Lasers Med Sci. 2016 Dec;31(9):1751-1759. doi: 10.1007/s10103-016-2045-1. Epub 2016 Sep 28.
The aim of this study was to evaluate the effects of low-level laser irradiation on the rate of orthodontic tooth movement (OTM) and the interleukin-6 (IL-6) concentration in gingival crevicular fluid (GCF) during orthodontic treatment. In this randomized split-mouth double blind clinical trial, 11 female patients aged 14 to 25 years (mean 19 ± 4.21 year), who required canine retraction following four first premolars extraction, were selected. The GaAlAs laser diode laser (A.R.C. Laser GmbH, Nürnberg, Germany) (980 nm, 100 mW, 5.6 J/cm, three points from the buccal side and three from lingual side of the tooth, 56 s, running in continuous mode) was used for canine retraction in only one maxillary quadrant (LG). The irradiation time for each cervical and middle third of the tooth was 10 s, and 8 s for the apical third of the tooth. The other maxillary quadrant served as the control group (CG) using the laser pseudo-application in this side. The laser irradiation was applied on days 0, 7, 14, 21, and 28 of each month during the canine retraction phase. Canine retraction was done using closed coil spring with 150 g force on rectangular wires after the alignment and leveling. This study was done in 11 months. Dental casts were made at different time points during the treatment, and the amount of tooth movement was measured. To evaluate the levels of IL-6, GCF samples were collected from the distal side of the maxillary canine teeth on both quadrants at the beginning of the trial, the end of aligning phase, and on day 21 of each month during canine retraction. Although the mean rate of canine retraction was higher in the LG (0.013) than the CG (0.012) and there was definitely a tendency for more canine retraction in the LLLI, but the results failed to show any significant difference between the mean rate of canine retraction of both groups (P = 0.068). A paired t test showed that there was no significant difference in the mean concentration of IL-6 at various stages of the treatment between the groups during canine distalization (P > 0.05). Therefore, conclusive evidence could not be provided to support the efficacy of the diode laser (980 nm) in accelerating OTM in female subject.
本研究的目的是评估低强度激光照射对正畸治疗期间正畸牙移动（OTM）速率以及龈沟液（GCF）中白细胞介素-6（IL-6）浓度的影响。在这项随机双盲半口对照临床试验中，选取了11名年龄在14至25岁（平均19±4.21岁）的女性患者，她们在拔除四颗第一前磨牙后需要内收尖牙。仅在上颌的一个象限（LG）中使用GaAlAs激光二极管激光器（德国纽伦堡A.R.C. Laser GmbH公司）（980nm，100mW，5.6J/cm，从牙齿颊侧三点和舌侧三点照射，56秒，连续模式）进行尖牙内收。牙齿每个颈部和中部三分之一的照射时间为10秒，根尖三分之一的照射时间为8秒。另一侧上颌象限作为对照组（CG），在此侧进行激光模拟照射。在尖牙内收阶段，每月的第0、7、14、21和28天进行激光照射。在排齐整平后，使用150g力的闭合曲弹簧在矩形弓丝上进行尖牙内收。本研究为期11个月。在治疗过程中的不同时间点制作牙模，并测量牙齿移动量。为了评估IL-6水平，在试验开始时、排齐阶段结束时以及尖牙内收期间每月的第21天，从两个象限上颌尖牙远中侧采集GCF样本。尽管LG组尖牙内收的平均速率（0.013）高于CG组（0.012），并且低强度激光照射组确实有更明显的尖牙内收趋势，但结果未能显示两组尖牙内收平均速率之间有任何显著差异（P = 0.068）。配对t检验表明，在尖牙远中移动期间，两组治疗各阶段IL-6的平均浓度无显著差异（P>0.05）。因此，无法提供确凿证据支持二极管激光（980nm）在加速女性患者OTM方面的疗效。
