Qin Jiaxuan, Xing Jinchun, Liu Rongfu, Chen Bin, Chen Yuedong, Zhuang Xuan
Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Oncotarget. 2017 Jun 28;8(60):102235-102243. doi: 10.18632/oncotarget.18704. eCollection 2017 Nov 24.
BACKGROUND/OBJECTIVE: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.
METHODS/MAIN RESULTS: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. 40 articles were included in our meta-analysis.
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
背景/目的：据报道，CD40基因rs1883832位点可能与免疫相关疾病易感性有关。由于研究结果不一且尚无定论，我们进行了一项病例对照研究的荟萃分析，以总结并阐明这种关联。
方法/主要结果：在多个数据库中对CD40基因rs1883832位点与免疫相关疾病易感性之间关联的研究进行了系统检索。采用比值比和95%置信区间来汇总效应量。我们的荟萃分析纳入了40篇文章。
CD40基因rs1883832位点与格雷夫斯病风险降低有关，尤其是在亚洲人群中；CD40基因rs1883832位点与多发性硬化症风险增加有关；CD40基因-1C>T（rs1883832）位点与桥本甲状腺炎、系统性硬化症或哮喘的易感性无关；尚无足够数据充分证实CD40基因rs1883832位点与系统性红斑狼疮（SLE）、类风湿关节炎（RA）、白塞病（BD）、重症肌无力（MG）、克罗恩病（CD）、溃疡性结肠炎（UC）、结节病、富氏葡萄膜炎综合征（FUS）、伏格特-小柳-原田综合征（VKH）、川崎病（KD）、巨细胞动脉炎（GCA）或免疫性血小板减少症（ITP）之间的关联。
