Wang Xiao-Xiong, Wang Xiao-Xia, Chen Tong
Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
EXCLI J. 2019 Jan 23;18:10-20. eCollection 2019.
This meta-analysis aims to evaluate whether the rs1883832 polymorphism is associated with Graves' disease (GD) risk in different populations. We performed a systematic literature search in China National Knowledge Infrastructure (CNKI), Web of Science, and Pubmed databases to identify case-control association studies on the association between rs1883832 and GD risk. For each study we calculated the odds ratios (OR) and 95 % confidence intervals (CI) assuming dominant, recessive and homozygote models. We then calculated pooled ORs and 95 % CIs. After applying inclusion and exclusion criteria, 17 studies involving 4707 cases and 4215 controls were included in the meta-analysis. The results showed that rs1883832 was associated with GD risk in Asians under dominant (CT + TT vs CC, OR=0.67, 95 % CI: 0.56-0.81, P<0.001), recessive (TT vs CT + CC, OR=0.58, 95 % CI: 0.47-0.72, P<0.001), and homozygote (TT vs CC, OR=0.49, 95 % CI: 0.37-0.64, P<0.001) models. In Caucasians, rs1883832 was associated with GD risk under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.68-0.99, P=0.042). Besides GD, we evaluated the relation of rs1883832 with Graves' ophthalmopathy (GO), finding that rs1883832 was associated with GO under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.69-0.98, P=0.031). The findings of our meta-analysis suggest that the rs1883832 polymorphism is protective against GD and GO in Asians and Caucasians.
本荟萃分析旨在评估rs1883832多态性是否与不同人群的格雷夫斯病（GD）风险相关。我们在中国知网（CNKI）、科学网（Web of Science）和PubMed数据库中进行了系统的文献检索，以确定关于rs1883832与GD风险关联的病例对照研究。对于每项研究，我们在显性、隐性和纯合子模型下计算优势比（OR）和95%置信区间（CI）。然后计算合并的OR和95%CI。应用纳入和排除标准后，17项涉及4707例病例和4215例对照的研究被纳入荟萃分析。结果显示，在显性模型（CT + TT vs CC，OR = 0.67，95%CI：0.56 - 0.81，P < 0.001）、隐性模型（TT vs CT + CC，OR = 0.58，95%CI：0.47 - 0.72，P < 0.001）和纯合子模型（TT vs CC，OR = 0.49，95%CI：0.37 - 0.64，P < 0.001）下，rs1883832与亚洲人的GD风险相关。在白种人中，在显性模型下（CT + TT vs CC，OR = 0.82，95%CI：0.68 - 0.99，P = 0.042），rs1883832与GD风险相关。除了GD，我们还评估了rs1883832与格雷夫斯眼病（GO）的关系，发现在显性模型下（CT + TT vs CC，OR = 0.82，95%CI：0.69 - 0.98，P = 0.031），rs1883832与GO相关。我们荟萃分析的结果表明，rs1883832多态性对亚洲人和白种人的GD和GO具有保护作用。
