Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Front Endocrinol (Lausanne). 2020 Jan 23;11:2. doi: 10.3389/fendo.2020.00002. eCollection 2020.
Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis. Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs. Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup. Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.
几项研究，包括一些全基因组关联研究（GWAS）表明，BAK1 基因 rs210138 多态性可能与睾丸生殖细胞肿瘤（TGCT）有关。在这里，我们试图通过系统评价和荟萃分析来总结这种关联。在数据库中系统地搜索与 BAK1 rs210138 和 TGCT 相关的研究。根据 OR 和 95%CI 汇总效应大小。我们的系统评价和荟萃分析包括 14 篇文章。在合格的 GWAS 和随访研究中，以及在总体组及其白人群组中，均发现 TGCT 的风险显著增加。与腺嘌呤（A）相比，BAK1 rs210138 鸟嘌呤（G）与 TGCT 的风险增加相关。需要进行设计良好的、具有更大样本量和更多亚组的研究来验证我们的系统评价和荟萃分析中确定的风险。
