Robuffo I, Toniato E, Tettamanti L, Mastrangelo F, Ronconi G, Frydas I, Caraffa Al, Kritas S K, Conti P
Institute of Molecular Genetics, CNR, Sede di Chieti, Italy.
Department of Medical, Oral and Biotechnologic Sciences, G. Dannunzio University, Chieti, Italy.
J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):837-842.
Innate immunity consists of physical and chemical barriers which provide the early defense against infections. Innate immunity orchestrates the defense of the host with cellular and biochemical proteins. Mast cells (MCs) are involved in innate and adaptive immunity and are the first line of defense which generates multiple inflammatory cytokines/chemokines in response to numerous antigens. MC-activated antigen receptor Fc-RI provokes a number of important biochemical pathways with secretion of numerous vasoactive, chemoattractant and inflammatory compounds which participate in allergic and inflammatory diseases. MCs can also be activated by Th1 cytokines and generate pre-formed and de novo inflammatory mediators, including TNF. IL-37 is an anti-inflammatory cytokine which binds IL-18R-alpha chain and reduces the production of inflammatory IL-1 family members. IL-37 down-regulates innate immunity by inhibiting macrophage response and its accumulation and reduces the cytokines that mediate inflammatory diseases. Here, we discuss the relationship between MCs, innate immunity, and pro-inflammatory and anti-inflammatory cytokines.
固有免疫由物理和化学屏障组成，这些屏障为抵御感染提供早期防御。固有免疫通过细胞和生化蛋白协调宿主的防御。肥大细胞（MCs）参与固有免疫和适应性免疫，是第一道防线，可针对多种抗原产生多种炎性细胞因子/趋化因子。MC激活的抗原受体Fc-RI会引发许多重要的生化途径，分泌大量血管活性、趋化和炎性化合物，这些化合物参与过敏性和炎性疾病。MCs也可被Th1细胞因子激活，并产生预先形成的和新生成的炎性介质，包括肿瘤坏死因子。白细胞介素-37（IL-37）是一种抗炎细胞因子，它与白细胞介素-18受体α链结合，减少炎性白细胞介素-1家族成员的产生。IL-37通过抑制巨噬细胞反应及其聚集来下调固有免疫，并减少介导炎性疾病的细胞因子。在此，我们讨论MCs、固有免疫以及促炎和抗炎细胞因子之间的关系。
