由化脓性链球菌侵袭性emm3/ST15菌株播散引起的链球菌中毒性休克综合征。
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes.
作者信息
Sekizuka Tsuyoshi, Nai Emina, Yoshida Tomohiro, Endo Shota, Hamajima Emi, Akiyama Satoka, Ikuta Yoji, Obana Natsuko, Kawaguchi Takahiro, Hayashi Kenta, Noda Masahiro, Sumita Tomoko, Kokaji Masayuki, Katori Tatsuo, Hashino Masanori, Oba Kunihiro, Kuroda Makoto
机构信息
Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Department of Pediatrics, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo, 187-8510, Japan.
出版信息
BMC Infect Dis. 2017 Dec 18;17(1):774. doi: 10.1186/s12879-017-2870-2.
BACKGROUND
Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing.
CASE PRESENTATION
A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015).
CONCLUSIONS
We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.
背景
化脓性链球菌（A组链球菌[GAS]）是一种主要的人类病原体，可导致广泛的临床表现。尽管侵袭性GAS（iGAS）感染相对不常见，但emm3/ST15 GAS是一种高毒力、侵袭性和致病性菌株。全球分子流行病学分析表明，最近emm3 GAS的频率一直在增加。
病例报告
一名14岁患者被诊断为链球菌中毒性休克综合征、严重肺炎、肾功能损害和横纹肌溶解。从气管内吸出物培养物中分离出GAS并命名为KS030。比较基因组分析表明，KS030被归类为emm3（emm型）和ST15（多位点测序分型[MLST]），这与在英国（2013年）和瑞士（2015年）鉴定的iGAS分离株相似。
结论
我们得出结论，emm3/ST15 GAS菌株的全球传播有可能导致侵袭性疾病。
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