/ST15 侵袭性感染：中国首例病例报告及全基因组分析
Invasive Infection With /ST15 : The First Case Report From China and Complete Genome Analysis.
作者信息
Mu Xinli, Wang Yanfei, Sun Lu, Zhao Shanshan, Jin Xi, Zhang Junli, Yu Yunsong, Wu Xueqing
机构信息
Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China.
Department of Clinical Laboratory, Shangyu People's Hospital, Shaoxing, China.
出版信息
Front Med (Lausanne). 2022 May 9;9:861087. doi: 10.3389/fmed.2022.861087. eCollection 2022.
(GAS) may cause severe invasive disease with a high fatality rate, especially M3-type strains, which are less common in China. Here, we report the first /ST15 invasive GAS infection case in China. The patient was diagnosed with severe skin and soft tissue infection (SSTI) and septicaemia caused by one GAS strain. Antibiotic susceptibility tests showed that the isolate was susceptible to all tested drugs. Antimicrobial therapy was then applied, and the patient fully recovered and was discharged from the hospital on Day 43. Whole-genome sequencing was carried out using the Illumina and Oxford Nanopore platforms and revealed this to be the first /ST15-type GAS invasive infection in China. The closely related /ST15-type GAS strains are MGAS315 from the United States and M3-b from Japan. Our finding is a warning that we should pay attention to invasive M3-type GAS infections in China and indicates the global spread of the highly virulent emm3/ST15 GAS strain.
A群链球菌（GAS）可能导致具有高致死率的严重侵袭性疾病，尤其是M3型菌株，在中国这种菌株较为少见。在此，我们报告中国首例/ST15侵袭性GAS感染病例。该患者被诊断为由一株GAS菌株引起的严重皮肤和软组织感染（SSTI）及败血症。药敏试验表明该分离株对所有测试药物敏感。随后进行了抗菌治疗，患者完全康复并于第43天出院。使用Illumina和牛津纳米孔平台进行了全基因组测序，结果显示这是中国首例/ST15型GAS侵袭性感染。与之密切相关的/ST15型GAS菌株是来自美国的MGAS315和来自日本的M3-b。我们的发现警示我们应关注中国的侵袭性M3型GAS感染，并表明高毒力emm3/ST15 GAS菌株在全球的传播。
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