Mooney S C, Hayes A A, MacEwen E G, Matus R E, Geary A, Shurgot B A
Donaldson-Atwood Cancer Clinic, Animal Medical Center, New York, NY 10021.
J Am Vet Med Assoc. 1989 Mar 1;194(5):696-702.
The records of 103 cats with lymphoma that underwent chemotherapy were reviewed. Diagnosis was confirmed by cytologic or histopathologic examination of appropriate tissue specimens. Sixty-four cats (62%) had a complete response to chemotherapy (median survival time, 7 months); 21 cats (20%) had a partial response (median survival time, 2.5 months); and 18 cats had a minimal response (median survival time, 1.5 months). Seventy-seven cats (75%) died of recurrent or progressive lymphoma, 9 cats died of feline leukemia-related anemia, 13 cats died of unrelated causes, and 4 cats were alive. Stage of disease was significantly (P = 0.009) related to response to treatment, and stage of disease and FeLV status were both significantly (P = 0.002 and P less than 0.001, respectively) related to survival.
回顾了103只接受化疗的淋巴瘤猫的记录。通过对适当组织标本进行细胞学或组织病理学检查来确诊。64只猫(62%)对化疗完全缓解(中位生存时间为7个月);21只猫(20%)部分缓解(中位生存时间为2.5个月);18只猫有最小反应(中位生存时间为1.5个月)。77只猫(75%)死于复发性或进行性淋巴瘤,9只猫死于猫白血病相关贫血,13只猫死于无关原因,4只猫存活。疾病分期与治疗反应显著相关(P = 0.009),疾病分期和猫白血病病毒(FeLV)状态均与生存显著相关(分别为P = 0.002和P < 0.001)。