Mahony O M, Moore A S, Cotter S M, Engler S J, Brown D, Penninck D G
Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
J Am Vet Med Assoc. 1995 Dec 15;207(12):1593-8.
To evaluate response to chemotherapy in cats with alimentary lymphoma and to determine factors associated with survival time.
Retrospective case series.
28 cats with alimentary lymphoma that underwent chemotherapy.
In all cats, the diagnosis had been established by means of cytologic or histologic examination of ultrasound-guided aspirates and biopsy specimens (18 cats), histologic examination of surgically obtained biopsy specimens (7 cats), or examination of specimens obtained endoscopically (3 cats). Clinical signs included anorexia, weight loss, vomiting, and diarrhea. Twenty-seven cats were treated with vincristine sulfate, cyclophosphamide, and prednisone; 1 was treated with chlorambucil and prednisone. Survival time ranged from 2 to 2,120 days (median, 50 days). Nine cats achieved complete remission (remission time ranged from 30 to 1,700 days; median, 213 days), 2 achieved partial remission, and 17 failed to respond to chemotherapy. Sex, FeLV status, hematocrit, serum total protein concentration, site and extent of gastrointestinal involvement, and clinical stage were not found to be associated with survival time.
Cats with alimentary lymphoma are poorly responsive to treatment with vincristine, cyclophosphamide, and prednisone; however, a small subset of cats may have long survival times.
评估患有消化道淋巴瘤的猫对化疗的反应，并确定与生存时间相关的因素。
回顾性病例系列。
28只接受化疗的患有消化道淋巴瘤的猫。
所有猫的诊断均通过超声引导下穿刺抽吸物和活检标本的细胞学或组织学检查（18只猫）、手术获取的活检标本的组织学检查（7只猫）或内镜获取标本的检查（3只猫）得以确立。临床症状包括厌食、体重减轻、呕吐和腹泻。27只猫接受了硫酸长春新碱、环磷酰胺和泼尼松治疗；1只猫接受了苯丁酸氮芥和泼尼松治疗。生存时间为2至2120天（中位数为50天）。9只猫达到完全缓解（缓解时间为30至1700天；中位数为213天），2只猫达到部分缓解，17只猫对化疗无反应。未发现性别、猫白血病病毒（FeLV）状态、血细胞比容、血清总蛋白浓度、胃肠道受累部位和范围以及临床分期与生存时间相关。
患有消化道淋巴瘤的猫对长春新碱、环磷酰胺和泼尼松治疗反应不佳；然而，一小部分猫可能有较长的生存时间。
