Murray-Stewart Tracy, Casero Robert A
Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Med Sci (Basel). 2017 Dec 18;5(4):38. doi: 10.3390/medsci5040038.
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues. Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs. This review summarizes the results of curcumin exposure with regard to the modulation of polyamine metabolism and discusses the potential utility of this natural compound in conjunction with the exploitation of dysregulated polyamine metabolism in chemopreventive and chemotherapeutic settings.
姜黄素（二阿魏酰甲烷）是一种天然多酚，是姜黄香料特有的黄色色素的来源，传统上以其抗氧化、抗炎和抗癌特性而闻名。姜黄素能够通过多种机制影响癌症发生的起始、促进和进展，在化学预防和化疗方面具有潜在用途。在人类癌细胞系中，姜黄素已被证明可降低鸟氨酸脱羧酶（ODC）的活性，ODC是多胺生物合成中的一种限速酶，在癌症和其他快速增殖组织中经常上调。大量研究表明，在针对各种器官的啮齿动物肿瘤发生模型中，用姜黄素预处理可消除致癌物诱导的ODC活性和肿瘤发展。本综述总结了姜黄素暴露对多胺代谢调节的影响结果，并讨论了这种天然化合物在化学预防和化疗环境中结合利用失调的多胺代谢的潜在用途。
