2015 年至 2017 年，通过综合监测和全基因组测序（WGS）发现丹麦和法国的冷熏三文鱼引起的李斯特菌病跨境暴发。
Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017.
机构信息
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
出版信息
Euro Surveill. 2017 Dec;22(50). doi: 10.2807/1560-7917.ES.2017.22.50.17-00762.
In August 2017, an outbreak of six listeriosis cases in Denmark was traced to cold-smoked salmon, using epidemiological investigations and whole-genome sequencing (WGS) analyses. Exchange of genome sequences allowed identification in France of a food isolate from a salmon-derived product and a human isolate from 2016 within the same cgMLST cluster as the Danish isolates (L2-SL8-ST8-CT771). The salmon product came from a third European Union country. WGS can rapidly link human cases and food isolates across Europe.
2017 年 8 月，丹麦暴发了 6 起因食用熏冷三文鱼而感染李斯特菌的病例，通过流行病学调查和全基因组测序（WGS）分析发现了这一事件的源头。对基因组序列的交换分析，使得法国能够鉴定出一种源自三文鱼产品的食品分离株和 2016 年的人类分离株，它们与丹麦分离株（L2-SL8-ST8-CT771）同属于一个 cgMLST 聚类。该三文鱼产品来自于第三个欧盟国家。WGS 可以快速将欧洲的人类病例和食品分离株联系起来。
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