Arana-Guajardo Ana Cecilia, Barrera-Torres Gustavo, Villarreal-Alarcón Miguel Ángel, Vega-Morales David, Esquivel-Valerio Jorge Antonio
Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
Universidad Autónoma de Nuevo León, Servicio de Gastroenterología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
Reumatol Clin (Engl Ed). 2019 May-Jun;15(3):165-169. doi: 10.1016/j.reuma.2017.09.005. Epub 2017 Dec 16.
The esophageal involvement in systemic sclerosis (SSc) causes impact in the morbidity and mortality. High resolution manometry assesses esophageal involvement. Our aim was to categorize esophageal motor disorder in patients with SSc by HRM.
We carried out an observational, descriptive and cross-sectional study. All patients underwent HRM as well as semi-structured interviews to assess frequency and severity of upper GI symptoms. Patients also completed the gastroesophageal reflux questionnaire (Carlsson-Dent).
We included 19 patients with SSc, 1 with morphea, and 1 with scleroderma sine scleroderma. Dysphagia and heartburn were the most frequent symptoms (61% each). We found an abnormal HRM in 15 (71.4%) patients. We found no statistically significant association between clinical or demographic variables and an abnormal HRM, or between any upper GI symptom and HRM findings.
We observed a high prevalence of esophageal symptoms and of HRM abnormalities. However, there was no clear association between symptomatology and HRM findings. HRM does not seem to accurately predict upper GI symptomatology.
系统性硬化症（SSc）累及食管会影响发病率和死亡率。高分辨率测压可评估食管受累情况。我们的目的是通过高分辨率测压（HRM）对SSc患者的食管运动障碍进行分类。
我们进行了一项观察性、描述性横断面研究。所有患者均接受了HRM检查以及半结构化访谈，以评估上消化道症状的频率和严重程度。患者还完成了胃食管反流问卷（卡尔森 - 登特问卷）。
我们纳入了19例SSc患者、1例局限性硬皮病患者和1例无皮肤硬化的硬皮病患者。吞咽困难和烧心是最常见的症状（各占61%）。我们发现15例（71.4%）患者的HRM异常。我们未发现临床或人口统计学变量与HRM异常之间、或任何上消化道症状与HRM结果之间存在统计学显著关联。
我们观察到食管症状和HRM异常的高患病率。然而，症状学与HRM结果之间没有明确关联。HRM似乎无法准确预测上消化道症状。
