内质网-线粒体接触：内质网中的肌动蛋白动力学通过钙释放控制线粒体裂变。
ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release.
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA.
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA
出版信息
J Cell Biol. 2018 Jan 2;217(1):15-17. doi: 10.1083/jcb.201711075. Epub 2017 Dec 19.
The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. https://doi.org/10.1083/jcb.201709111) demonstrate that INF2 mediates actin polymerization at the endoplasmic reticulum (ER), resulting in increased ER-mitochondria contacts, calcium uptake by mitochondria, and mitochondrial division.
formin 样蛋白 INF2 是肌动蛋白丝聚合的重要参与者。在本期中，Chakrabarti 等人（2018. https://doi.org/10.1083/jcb.201709111）证明，INF2 在内质网上介导肌动蛋白的聚合，导致内质网-线粒体接触增加、线粒体摄取钙和线粒体分裂。
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