Kobayashi Hideyuki, Tamura Koji, Tai Toshihiro, Nagao Koichi, Nakajima Koichi
Department of Urology Toho University School of Medicine Tokyo Japan.
Reprod Med Biol. 2017 Jul 7;16(4):320-324. doi: 10.1002/rmb2.12044. eCollection 2017 Oct.
Oncofertility is a subspecialty that is concerned with helping patients with cancer preserve their ability to have children in the future. For men, sperm banking is an established way to preserve fertility. The aim was to determine the prefreeze semen characteristics and reproductive outcomes according to cancer type for men who chose semen cryopreservation.
The records of 122 men with cancer who requested semen cryopreservation at the authors' hospital from 2006 to 2015 were reviewed. The mean patient age when the semen was cryopreserved was 33.6 years.
The 122 men who banked sperm during the study period had the following types of cancer: testicular (44.3%), hematological (31.1%), digestive (8.2%), and other types (16.4%). The mean sperm concentration by cancer type was 30.5 × 10/mL for testicular, 45.0 × 10/mL for hematological, 40.5 × 10/mL for digestive, and 68.4 × 10/mL for the other types. The mean sperm motility by cancer type was 59.6% for testicular, 50.1% for hematological, 43.0% for digestive, and 44.8% for the other types. For 12 (9.8%) men who used the banked semen, there were five (41.7%) clinical pregnancies.
Semen cryopreservation is a simple procedure that can be accomplished quickly and can preserve fertility.
肿瘤生育学是一个亚专业领域，致力于帮助癌症患者保留未来生育的能力。对于男性而言，精子冷冻保存是一种既定的生育力保存方法。本研究旨在确定选择精液冷冻保存的男性患者，根据癌症类型的冻前精液特征及生殖结局。
回顾了2006年至2015年期间在作者所在医院要求进行精液冷冻保存的122例癌症男性患者的记录。精液冷冻保存时患者的平均年龄为33.6岁。
在研究期间进行精子冷冻保存的122例男性患者所患癌症类型如下：睾丸癌（44.3%）、血液系统癌症（31.1%）、消化系统癌症（8.2%）和其他类型癌症（16.4%）。按癌症类型划分，睾丸癌患者的平均精子浓度为30.5×10⁶/mL，血液系统癌症患者为45.0×10⁶/mL，消化系统癌症患者为40.5×10⁶/mL，其他类型癌症患者为68.4×10⁶/mL。按癌症类型划分，睾丸癌患者的平均精子活力为59.6%，血液系统癌症患者为50.1%，消化系统癌症患者为43.0%，其他类型癌症患者为44.8%。在12例（9.8%）使用冷冻精液的男性中，有5例（41.7%）实现了临床妊娠。
精液冷冻保存是一种简单的操作，可快速完成并能保存生育力。
